Martin, a mentally disturbed loner who lives with his nagging mother on a bleak London council estate, where loud neighbours and squalid living conditions threaten to plunge this victim of sexual and psychological abuse over the edge. Working the night shift as an attendant at an underground car park, he indulges his obsession with The Human Centipede (First Sequence) watching the film over and over on a laptop in his office and meticulously examining the scrapbook he has lovingly filled with memorabilia from the film, including the ass-to-mouth surgery instructions made famous by Dr. Heiter, the mad scientist from Martin's favorite film. Pushed to the brink by his belligerent mother and haunted by the teasing voices of his abusive and imprisoned father, Martin sets into motion his plan to emulate Heiter's centipede by creating his own version. In a rented warehouse, he begins to acquire victims, including his loud, violent neighbour, a prostitute and her lecherous client, and several more… including Martin's pièce de résistance, one of the actresses from The Human Centipede (First Sequence). Although lacking the medical skills of his hero, Martin soldiers on with grotesque DIY gusto, armed with a healthy supply of duct tape, household tools and staple guns!

What follows is one of the most harrowing and terrifying films ever conceived, featuring a central character that makes Dr. Heiter seem tame in comparison. The Human Centipede 2 (Full Sequence) is a triumph in biological body-horror by Tom Six, one of the new masters of the horror genre.